Nka kimwe mu bintu bikoreshwa cyane muburyo bwo gufata imiti, ibiranga rehidrasiyo ya gelatine irimo capsules yubusa nibyingenzi kugirango hamenyekane ubuziranenge n’imitunganyirize y’imiti. Rehydration bivuga inzira ya gelatin capsules iva mubintu byumye cyangwa ibirahure bigasubira muburyo bwambere bwo kubyimba n'imbaraga za mashini mubihe bidasanzwe. Ibi biranga biha capsules neza ubushobozi bwubwenge bwo gukora, bibafasha kugira uruhare runini mugutanga ibiyobyabwenge.
Imiterere ya Physicochemical of Rehydration
Kuvugurura gelatine ya capsules yubusa ni ihinduka ryiminyururu ya molekuline ya gelatine kuva kumurongo uteganijwe ukajya muburyo bwabyimbye. Mugihe cyumye, molekile ya gelatine ikora urusobe rukomeye binyuze mumigozi ya hydrogène, bikavamo imiterere ikomeye kandi yoroheje. Iyo uhuye n’amazi cyangwa amazi yumubiri, molekile zamazi zinjira kandi zigahungabanya iyo miyoboro ya hydrogène, bigatuma iminyururu ya molekile irekura kandi re - ikora urusobe rwa hydrogel eshatu -. Ubu buryo bugaragazwa cyane nubushyuhe, pH, nimbaraga za ionic: mugihe cya dogere 37 (hafi yubushyuhe bwumubiri) hamwe nibidukikije bidafite aho bibogamiye, igipimo nigipimo cya rehidrasiyo byateguwe neza, bigatuma capsule isenyuka vuba muri vivo mugihe birinda kworoshya imburagihe mugihe cyo kubika kubera kwinjiza amazi.
Ibyingenzi Byibanze bya Rehydration Ibiranga
Ibiranga rehidrasiyo bigaragarira cyane cyane mubintu bitatu: icya mbere, kubyimba kinetics - hejuru - capsules nziza irashobora kurangiza kubyimba muminota 10-15 mumazi yigana amara, hamwe no kubyimba bigera ku nshuro 5-8 z'ubunini bwambere, bigatuma ibiyobyabwenge bisohoka mugihe; icya kabiri, kugarura imbaraga za mashini - nyuma yo kongera kwisubiramo, imbaraga zavunitse za capsule zigomba kuguma hagati ya 1.5-2.5N · mm⁻², bihagije kugirango bikubiyemo ibintu kandi bikomeze kuba byiza mugihe cyo gutwara; icya gatatu, gusenyuka kwa syncronisme, urukuta rwa capsule rwongeye gushonga rusa kimwe mubidukikije bya pH, bikarinda kurekura ibiyobyabwenge byaho kandi bikongera bioavailability.
Agaciro kingenzi mubikorwa bya farumasi
Mu gufata ibiyobyabwenge, ibiranga rehidrasiyo bigira ingaruka nziza kubikorwa byo kuvura. Kuri capsules ya enteric, ni ngombwa kugenzura igipimo cya rehidrasiya hifashishijwe ikoranabuhanga rya coating, bikarinda umutekano muke wa gastricide acide mugihe utuma rehidrasiyo yihuta kandi igacika nyuma yo kwinjira mumara. Kuburyo bukomeza - kandi bugenzurwa - bwo gusohora, igipimo cya rehidrasiya hamwe n umuvuduko wo gushiraho urwego rwabyimbye hamwe bigena umwirondoro wo gusohora ibiyobyabwenge. Byongeye kandi, rehidrasiyo ni ikintu cyingenzi cyerekana ubuzima bwa capsule - mugihe cya dogere 25 na 60% ugereranije nubushuhe bugereranije, capsules nziza - zishobora gukomeza gukora rehidrasiyo mumyaka irenga ibiri, bigatuma ubuzima bwiza bwibiyobyabwenge.
Ibiranga rehydrasiya yagelatin capsulesbyerekana ihuriro ryibikoresho siyanse, chimie physique, na farumasi. Hamwe niterambere ryibikoresho byubwenge, mubyukuri guhuza imyitwarire ya rehidrasiyo muguhindura amasoko ya gelatine (urugero, igipimo cyubwoko A na Ubwoko B gelatine), impamyabumenyi ihuza imipaka, hamwe nimpinduka zifatika zirashobora gutanga abatwara ibintu byiza mugutanga ibiyobyabwenge, kurekura pulsatile, nibindi bitekerezo bishya - guhora utera udushya muri sisitemu yo gutanga ibiyobyabwenge. Niba hari ibisabwa kuri capsules yubusa, ikaze kuvugana na KornnacCaps.
