Mu nganda zimiti nintungamubiri, capsules yubusa ikora ibiyobyabwenge. Imikorere yabo yibanze ntabwo ikubiyemo ibintu gusa, ariko cyane cyane, guturika bidatinze ahantu runaka mumubiri kugirango barekure ibiyobyabwenge. Igihe ntarengwa cyo gusenyuka bivuga igihe gikenewe kugirango capsule ihinduke iva muri leta ihamye ihinduke leta idakumirwa muburyo bwihariye; iki nikimenyetso cyingenzi cyo gupima ubuziranenge bwa capsule. Bitewe nuburyo butandukanye bwimiterere yimiterere nimiterere yumubiri, ubwoko butandukanye bwa capsules yubusa bugaragaza itandukaniro rikomeye mugihe cyo gusenyuka kwabo.
Kugeza ubu, imiyoboro rusange yubusa ku isoko igabanijwemo cyane cyane muri gelatine capsules (inyamaswa - ikomoka) hamwe na capsules yimboga (cyane cyane HPMC capsules na Pullulan capsules).
Ubwa mbere,gelatin capsulesni dosiye ya dosiye isanzwe hamwe namateka maremare. Ibyingenzi byingenzi bikomoka ku ruhu rwinyamaswa hamwe namagufa ya kolagen, afite hydrophilique nziza. Mu bidukikije bisanzwe byamazi (dogere 37, imiyoboro y'amazi), capsules ya gelatine ikurura amazi kandi ikaguka vuba, hamwe nigishishwa cyoroshye kandi kigashonga. Ukurikije Pharmacopoeia yo mu Bushinwa hamwe n’ibipimo bifatika, igihe ntarengwa cyo gusenyuka kwa gelatine capsules gisanzwe gisabwa kuba mu minota 30. Bitewe n'amazi yabo - imiterere ya elegitoronike, capsules ya gelatine itanga vuba kandi niyo ihitamo kumiti myinshi.
Icya kabiri,HPMC capsulesni capsules zikoreshwa cyane. Bitandukanye na gelatine, HPMC ikomoka kuri selile ifite imiterere ihamye. Uburyo bwo gusesa HPMC capsule mumazi bifitanye isano rito nubushyuhe kandi ntabwo bigira ingaruka cyane kubiciro bya pH. Nubwo igihe cyabo cyo gusenyuka nacyo cyujuje ibya farumasi ya farumasi mu minota 30, capsules ya HPMC ikunze kwerekana imyitwarire idahwitse yo gusenyuka mugihe nyacyo cyo guseswa. By'umwihariko mubushyuhe buke - ubushyuhe cyangwa hejuru - ahantu h’ubushuhe, capsules ya HPMC ikomeza ubwitonzi nubushake; ntibababazwa nigihe kinini cyo gusenyuka kubera umusaraba - uhuza reaction (gusaza) nkuko capsules ya gelatine rimwe na rimwe ibikora.
Mubyongeyeho, kubikenewe bidasanzwe, hariho enteric - zifunze capsules kandi zikomeza - kurekura capsules. Hatitawe ku kuba matrix ari gelatine cyangwa fibre yibihingwa, enteric - capsules yometseho imiti idasanzwe yo kuvura cyangwa guhindura imiti. Ntibisenyuka mubidukikije bya aside gastricike kandi bigashonga nyuma yo kwinjira mubidukikije bya pH by amara. Igihe ntarengwa cyo gusenyuka gisabwa kuba mugihe cyisaha 1 mumazi yo munda yubukorikori, biri mubyiciro byo kurekurwa.
Muncamake, capsules ya gelatine isanzwe hamwe na capsules yimboga bifite igihe gisa nigihe cyo gutandukana (haba muminota 30), ariko capsules yimboga ikora neza mubijyanye no gutuza mubihe bikabije no kurwanya gusaza. Mugihe uhitamo ubwoko bwa capsule, uruganda rukora imiti rugomba gusuzuma byimazeyo imiterere yibiyobyabwenge, imiterere yububiko, nibisabwa kugirango umuvuduko ukabije kugirango ibiyobyabwenge bibe byiza.
