Nkumutwara wingenzi mubikorwa bya farumasi bigezweho,enteric-capsuleszikoreshwa cyane mu nganda zimiti kubera ibyiza byazo, nka site isobanutse - irekurwa ryihariye, kurinda ibiyobyabwenge kurimburwa na aside gastricike, no kwirinda ibiyobyabwenge kurakaza mucosa gastric. Nyamara, mugihe cyo kubyara no kubika nyirizina, igihe cyo gusenyuka kwa enteric capsules akenshi nikimenyetso cyingenzi cyerekana ubuziranenge bigoye kugenzura. Gutinda gutinda cyangwa kurekurwa imburagihe bigira ingaruka ku buryo butaziguye bioavailability hamwe nubuvuzi bwiza bwibiyobyabwenge. None, ni ibihe bintu mubyukuri bigira uruhare mu gusenyuka kwa enteric - capsules?
Mbere na mbere, ibigize hamwe nimiterere yibikonoshwa nibintu byingenzi byerekana imikorere isenyuka.Imbere ya capsulesKoreshagelatinnkibikoresho fatizo, byunganirwa na polymeric enteric nka acrylic resin, selile acetate phthalate (CAP), cyangwa shellac. Iseswa ryibi bikoresho byinjira bishingiye ku gaciro ka pH yibidukikije byo munda. Niba igipimo cyo gutondekanya ibintu byinjira muri enteric bidakwiye - urugero, niba igipimo cya firime - cyerekana ibintu ari kinini cyane - gishobora kuvamo igikonoshwa kidashobora gushonga cyangwa kwangirika vuba mumazi yo munda, bityo bigatuma gusenyuka kurenza igihe ntarengwa. Byongeye kandi, gelatin ubwayo ifite uburabyo, ubukonje, hamwe nurwego rwumusaraba - ihuza reaction nayo igira ingaruka kuburyo butaziguye kwinjiza amazi no gukwirakwiza igikonoshwa cya capsule.
Icya kabiri,inzira yo gukoranuburyo bwo kubika bugira uruhare runini. Mubikorwa bya capsule, kugenzura ubushyuhe bwumwanya nigihe birakenewe cyane. Kuma cyane birashobora gutuma habaho ubushyuhe buke cyane mugikonoshwa, bigatuma buvunika cyane kandi bukomeye, bigira ingaruka kumazi no kwinjira mumazi yumubiri; muburyo bunyuranye, ubuhehere burenze urugero burashobora gutuma igikonjo cyoroha cyangwa gihinduka. Ndetse cyane cyane ni uko ubuhehere, ubushyuhe, n'umucyo muriibidukikijeirashobora gukurura "umusaraba - guhuza" reaction muri gelatin. Uyu musaraba - ingaruka zo guhuza zikora amazi - imiterere y'urusobekerane rw'urusobe hejuru yikibabi, bigatuma capsule idashobora kwinjiza amazi no gusenyuka bisanzwe nyuma yo kwinjira mumubiri wumuntu, ibintu bizwi cyane nka "insolubility".
Hanyuma, imiterere yibikoresho byuzuye ntishobora kwirengagizwa. Nubwo gusenyuka byibanda cyane cyane mugikonoshwa, ingaruka zibirimo nukuri kubintu bifatika. Niba imiti yuzuye ifite aside irike cyangwa alkaline, cyangwa irimo aldehydes nyinshi, irashobora kwihutisha imiti yimiti hamwe nigikonoshwa, bikabangamira ituze ryurwego rwinjira. Ibi birashobora gutuma umuntu aturika imburagihe mu gifu cyangwa bikabuza kurekura bisanzwe mumazi yo munda.
Muri make, ibintu bigira uruhare mu gusenyuka kwa capsules yubusa irimo ibintu byinshi, harimo imiterere yimiti yibikoresho fatizo, kugenzura ibipimo byumusaruro, hamwe nuburinganire bwibidukikije. Uruganda rwa farumasi rugomba kugenzura neza ubwiza bwibikoresho fatizo, guhuza uburyo bwo kumisha, no kwemeza ahantu heza kandi humye. Gusa mugucunga neza ibi bintu dushobora kwemeza ko capsules ya enteric - isenyutse kandi ikarekura neza kandi neza mumubiri, bityo tukemeza ko imiti ivura imiti.
